Biography:

Michael Ian Rothenberg, Ph.D, LCSW is a Board Certified Clinical Sexologist, Certified Sex Therapist, Psychotherapist and the Founder and Clinical Director of the Center for Counseling and Sexual Health of Winter Park, Florida. As a sexuality educator, Dr. Rothenberg has held a long term faculty position, in Orlando, Florida, at the University of Central Florida (UCF), School of Social Work, where he developed the curriculum in Human Sexuality and taught courses on human sexuality and sexual behavior. Dr. Rothenberg, a former Hospice Social Worker, credited with developing the Sexological sub-field of Thanatological Clinical Sexology (the study of sexuality, death and dying), has published and been quoted in numerous articles relating to human sexuality and lectures, both nationally and internationally, at universities, hospitals and hospices, on topics related to human sexuality, sexual behavior and sexual health. 

Abstract:

Introduction: Human beings are sexual beings from birth until death. This presentation explores sex and sexuality at the end of life and the importance of establishing a dialogue between patients and clinicians as an integral part of end of life care. Objectives: To identify and understand barriers and challenges in discussing sex and sexuality at the end of life and establish a methodology for better communication.Methods: A qualitative methodological approach was utilized and the resultant data will be presented as case histories gathered in the context of clinical sexology consultations.Results: As discomfort and physical pain, at the end of life, can be controlled through the proper use of medication, psychological and emotional distress, directly and indirectly, related to sex and sexuality, can be ameliorated through specific conversation and dialogue. Conclusion: This presentation hopes to raise important questions about the palliative care professional's responsibility regarding the understanding of sexuality for individuals in the end of life stage as well as illustrate how to begin to engage in needed discussions on sex and sexuality.

Biography:

Shin-ichi Kayano graduated from the Department of Food Science and Nutrition, Faculty of Human Life Science, Osaka City University, Japan, in 1985. He worked as a Senior Researcher of research institute, Miki Corporation, Japan, from 1985 through 2004. His job in Miki Corporation was the development of new products of functional foods, and study on functional components in fruits and vegetables. He was awarded a PhD in Science in 2004, from Osaka City University, Japan, under the supervision of Professor Nobuji Nakatani. He joined the Kio University as a Professor in 2009. His current study is on the antioxidative, antimutagenic, and estrogenic ingredients in various fruits and vegetables, and the elucidation of chemical structures and action mechanism of these compounds.

Abstract:

Dried fruits of persimmon (Diospyros kaki Thunb.) are a traditional food in Japan and contain large quantities of tannins. In this study, we investigated the in vitro and in vivo antioxidant potentials of non-extractable fractions from dried persimmons. Hydrolysed non-extractable fractions showed the highest antioxidant activities in vitro. In subsequent experiments, the plasma oxygen radical absorbance capacity (ORAC) values in rats supplemented with 5% non-extractable fraction were approximately 1.5 times higher than those in control rats after 1 week in vivo. Furthermore, using an in vitro model of the gastrointestinal tract, the ORAC values of the non-extractable fraction were significantly increased with colonic fermentation in the large bowel stage. These data indicate that non-extractable fractions may possess significant antioxidant potential in vitro and in vivo.

Biography:

Magnus S Magnusson, Research Professor. PhD in 1983, University of Copenhagen. He is the author of the T-pattern and the T-systeem model, initially focused on the real-time organization of behavior, that forms the basis of his corresponding dedicated pattern detection software THEMEtm. He has co-directed a two year DNA analysis project. He has published numerous papers and given invited talks and keynotes at international athematical, neuroscience, proteomics, A.I., bioinformatics and science of religion conferences and at leading universities in Europe, USA, and Japan. Deputy Director 1983-1988, Anthropology, National Museum of Natural History, Paris. Then he has repeatedly invited temporary university Professor in psychology and ethology (biology of behavior) at the University of Paris (V, VIII & XIII). Since 1991, founder and director of the Human Behavior Laboratory, University of Iceland. He Works in formalized collaboration between now 32 European and American universities based on “Magnusson’s analytical model” initiated at University René Descartes Paris V, Sorbonne, in 1995.

Abstract:

This talk concerns spatial and temporal self-similarity across more than nine orders of magnitude, implicating a self-similar fractal-like pattern, called T-pattern, a natural or pseudo-fractal pattern, recurring with statistically significant translation symmetry. The T-pattern, the core of the T-system of structural concepts is a result of an ethological (i.e. biology of behavior)  project started in the early 1970’s primarily on social interaction and organization in social insects and primates including humans inspired mainly by the ethological work of Lorenz, von Frisch and Tinbergen for which they shared a Nobel Prize in Medicine or Physiology in 1973. Notably, in this context, their smallest subjects were social insects and thus no consideration of selfsimilarity. The present project has focused on developing time pattern definitions with corresponding detection algorithms resulting in the T-pattern type and the dedicated THEME software, which has allowed their abundant detection in many kinds of animal and human behavior and interactions and later in neuronal interactions within living brains, thus showing T-patterned self-similarity of temporal  interaction between and within brains. The RNA world invented its evolving external memory as the purely informational giant T-patterned DNA strings and now there is only a DNA world. Similarly, billions of years later,humans invented their evolving external memory as the purely informational T-patterned strings (T-strings) of written language that have made possible, in a biological eye-blink, the development of modern science and technology and the creation of extremely populous and complex human mass-societies, the only mass-societies among large-brained animals and recent discoveries of the nanoworld of cells and molecules. Protein and human mass-societies seem to be the only ones using such durable giant T-strings external to their citizens. Human and protein  masssocieties create their specialized citizens using various sub-sections of such T-strings, not found, notably in social insect societies. Extensive temporal and spatial self-similar patterning thus seems to exist in form and function from nano to human temporal and spatial scales suggesting structural, functional and organizational principles.

Biography:

Full Professor of Histology and Embriology, University of Padova, Italy.

Graduated as MD (University of Padua, 1965), Postodctoral Specialization in Clinical Pathology (University of Padua, 1977), Postdoctoral Fellow Dept. of Biochemistry, Baylor University of Baylor, Houston, Texas, Usa, (1965-1967), Lecturer, Institute of Histology, University of Padua (1970), Full Professor of Histology - Embriology, University of Padua (1975 - 2011)

Senior Researcher of the Faculty of Medicine- University of Padova (2012- present)
President of the Italian Society of Cutaneous Biology and Member of the Editorial Board of "Wound Repair and Regeneration" (Mosby Inc., St. Louis MO, USA).

Abstract:

Introduction

Giovanni Abatangelo, Senior Researcher, University of Padova, Faculty of Medicine, Italy

Nociceptive pain is one of the most common types of pain and originates with an injury involving nociceptors. About 60% of the knee joint innervations are classified as nociceptive. The specific biological mechanism underlying the regulation of nociceptors is relevant for symptom treatment of pathologies affecting the knee joint. Indeed, intra-articular administration of exogenous hyaluronic acid (HA) in osteoarthritis (OA) seems to be particularly effective reducing pain and improving patient function. In the present work we investigated if HA induces activation of opioid peptide (OP) receptors.

Methods

In the present work we used both aequorin technology and the fluorescent dye Fura-2 to investigate if HA is able to induce putative antinociceptive effects via opioid receptor activation.

Results

Treatment with medium molecular weight (200 kDA) HA induces the selective activation of the kappa (KOP) receptor.

Conclusions

The relief of pain associated with HA treatment appears to be a direct action of HA to a specific antinociceptive receptor such as the KOP receptors present in the plasma membrane of nociceptors.

Biography:

Robert P Foglia, MD is Professor of Surgery and Pediatrics, Chief of Pediatric Surgery at the University of Southwestern Medical Center and Surgeon-in-Chief at Children’s Medical Center Dallas. He is Co-editor of a major textbook of pediatric surgery and has 30+ years of experience in Perioperative Management and Performance Improvement. He is responsible for the clinical growth of surgical programs at Children’s and Leads Process Improvement Initiatives in the areas of quality, service and stewardship. 

Abstract:

Our health system had a strategic plan to recruit surgeons, develop new programs and shift volume outside of the Main OR (MOR) suite. Previously, many of perioperative processes were dysfunctional, data with paper charting often had inaccuracies, and physicians had a healthy skepticism of the data, leading to a lack of engagement. Our aims included optimizing space, personnel, and processes, developing performance metrics, setting clear expectations for resource allocation and sharing credible data with stakeholders. Perioperative performance improvement is the orchestration of a multidisciplinary team to achieve a series of goals, which are sustainable. Three elements were essential to achieve these goals, prompt communication with shared goal expectation, operations management, and the electronic health record (EHR).

The results from 2006 to 2015 were: a) cases increased from 19,148 to 29,308 (53%), b) block utilization increased from 47% to 72% (+53% ), c) on time starts increased six-fold (12% to 80%), d) case cancellations reduced 3-fold (14% to 4%), e) MOR cases increased +2%, f) cases outside of MOR increased from 5,606 to 15,443 (+175%), while MOR cases increased 2%, g) revenue increased 99%, from $116M to $231M in 2015. Prompt and consistent communication with physicians and perioperative leadership, the use of operations management to change processes, and the EHR resulted in marked improvement in multiple performance metrics and a concomitant increase in engagement and "buy in" by physicians, administrative and nursing leadership.

Biography:

Rudolf Lucas obtained his PhD in cellular and genetic biotechnology in 1993 summa cum laude from the Free University of Brussels, Belgium (VUB) and he currently holds a faculty position at the Medical College of Georgia. He is currently Chair of the American Heart Association Lung Fellowship Committee. His expertise mainly

lies in the development of novel therapeutic candidates to treat pulmonary edema. Over the past 20 years, his research has led to the discovery of a TNF-derived peptide, Solnatide, which is a direct activator of the epithelial sodium channel. This peptide has shown promising activities in two recently finalized phase 2a clinical trials in patients with acute lung injury and upon lung transplantation.

Abstract:

Efficient exchange of oxygen and carbon dioxide between the lung capillaries and the alveoli requires that the latter is kept dry. Vectorial Na+ transport through the apically expressed epithelial sodium channel (ENaC), and the basolaterally expressed Na+-K+-ATPase mediates Alveolar liquid Clearance (ALC) in type 1/2 alveolar epithelial cells. ENaC activity is defined by the product of its open probability time and its membrane surface expression. The alpha subunit of ENaC also associates with the acid-sensing ion channel to form the hybrid Non-Selective Cation (NSC) Channel, which also contributes to ALC. In conditions of ARDS and severe pneumonia, which are associated with intense pulmonary inflammation, ENaC function can become impaired. Moreover, pathogen-associated toxins, as well as pro-inflammatory cytokines can disrupt capillary endothelial barriers, causing fluid to leak from the capillaries into the alveolar space. The resulting Pulmonary Permeability Edema (PPE)

is a potentially lethal complication, for which no proven pharmacological treatment exists to date. The identification of novel

therapeutics for PPE is therefore of the utmost importance. Solnatide is a TNF-derived peptide that mimics the lectin-like domain of tumor necrosis factor, the latter of which is spatially distinct from the receptor binding sites1-4. Solnatide binds to the alpha subunit of ENaC and as such increases the open probability, as well as surface expression of the channel, even in the presence of bacterial toxins, such as Pneumolysin (PLY), the main virulence factor of Streptococcus pneumoniae. The peptide also prevents bacterial toxin-induced endothelial barrier dysfunction in lung microvascular endothelial cells, which express both ENaC and NSC channels and has potent anti-inflammatory actions. The therapeutic potential of Solnatide was recently evaluated in two phase clinical trials in patients with acute lung injury and lung transplantation. The results of the pre-clinical and clinical studies will be discussed in this contribution.

Biography:

Abstract:

Biography:

Αggeliki Pappa is the Founder of “i love dyslexia” (ILD), the first and only highly specialized, innovative edu-organization internationally, for holistic EFL-FL teaching to students with dyslexia and SEN. She has built ILD innovative tools and holistic study program after years of research, innovative edu-practice and teaching, and she collaborates with Folkuniversitetet, Uppsala on European projects as a Teacher Trainer. ILD has been nominated for UNESCO Hamdan Prize, was included in the top 10 innovations in Greece by ‘Greece Innovates’ competition and has have been recognized by the Greek Ministry of Education and the Ministry of Development. She was included in the Top 50 educators in the world for the Global Teacher Prize-2016 and is the Leader of the Varkey Teachers Ambassadors literacy group, collaborating with Prof. Reimers, Harvard, USA. Her passion and vision is the creation of quality education for all, for sustainability, love and peace in the world.

Abstract:

According to “Dyslexia International” 10 to 15% of global population has dyslexia, putting more than 700 million children and adults worldwide at risk of life-long illiteracy and social exclusion. A major problem of today’s education for students with dyslexia and special educational needs (SEN) is education system constraints which prevent learners from being effectively included in the learning process of a foreign language (FL) depriving them of a necessary life skill and a global voice. There is no common European methodology on teaching English as a foreign language (EFL) and FL to students with SEN, with the big majority of educators lacking awareness and practical knowledge on this still quite unexplored field. The award winning ‘i love dyslexia’ (ILD) in Athens, Greece is the first and only internationally, highly specialized school for holistic EFL-FL learning to students (children and adults) with dyslexia and SEN, introducing an innovative combination of authentic and complete FL tool collection and a pioneering multi-level program set to fill the big gap for effective EFL-FL access for millions of students with SEN worldwide, while its system could be implemented in settings where English is taught as a first language. ILD highly structured tool combination and holistic program of studies are designed based on brain targeted teaching, shelf awareness sessions, design thinking and mind mapping, smart multisensory mnemonics, synthetic and analytic teaching, drama and project passed differentiated activities, use of new technology and augmented reality tools in combination with activities in outdoor natural environment, as well as mindfulness and Aikido as educational tools to develop inner harmony and meet challenges of living to thrive in life. Last but not least, ILD provides experiential training courses on EFL-FL and SEN, empowering educators worldwide with practical knowledge and effective tools to support all their students succeed in EFL-FL learning.

Biography:

Azza Mahmoud Kamel is currently working as Emirate Professor of Clinical Pathology at National Cancer Institute, Cairo University, Egypt since 2007. Previously she worked as Professor of Clinical Pathology (1986- 2007) at National Cancer Institute, Cairo University, Egypt, Founder and Head of BMT Lab. Unit (1993- 2007) and Head of Clinical Pathology Department (2005-2007). She pursued her Medical Degree (MB, BCh), Faculty of Medicine, Cairo University (June 1968), Master Degree (MSc) in Clinical Pathology, Faculty of Medicine, Cairo University (October 1972) and Doctorate Degree (MD) in Clinical Pathology(Immunology/ Hematology), Faculty of Medicine, Cairo University (July 1976). She has 165 publications in many reputed journals. She conducted many workshops and completed many research projects. She received many awards like State Award in Medicine (1989), Medal of Excellence from the Egyptian Government (1994). She is an active member of Egyptian Society of Cancer, International Society of Hematology, European and African division (ISH), European Association of Hematology (EHA), American Association of Cancer Research (AACR), International Society of Thrombosis and Hemostasis (ISTH).

Abstract:

Cell-free indicates DNA that is found freely in the blood without a nucleus. Circulating cell-free DNA (ccf-DNAs) were first identified by Mandel and Metais in 1948 but their association with disease was not confirmed till 1977 when their increased level in the plasma/serum of cancer patients was proved. In healthy individuals, the main source of ccf-DNA is apoptotic cells which release uniform DNA fragments 185 to 200 base by a programmed enzymatic cleavage; the level is extremely variable but is usually low to negligible. Cancer cells release different and longer DNA fragments resulting from necrosis, autophagy, or mitotic catastrophe; the chance of an active release from cells was also reported and the levels are much higher than in healthy individuals. However, increased levels of ccf-DNA were observed in many diseases including leukemia, solid tumors, pulmonary embolism, myocardial infarction, tissue trauma, and chronic inflammatory diseases. This broad prevalence of diseases with potentially elevated ccf-DNA levels limits the diagnostic specificity and no cutoff value of plasma DNA concentration produced performance characteristics that would make it a good screening tool for neoplastic diseases. Thus a more refined approach was applied by calculating the ratio between cancer cell-derived ccf-DNA and normal cell-derived ccf-DNA in what is called DNA integrity index. More recently detection of tumor-specific molecular aberrations in the ccf-DNA is performed, what is called liquid biopsy. Many studies reported increased serum concentration and DNA integrity index in various solid tumors including breast, gynecological malignancy, HCC and acute myeloid leukemia. The analysis of the length of circulating DNA in plasma was reported as a sensitive marker for solid tumor detection and it was claimed to discriminate between benign and malignant lesions. The rationale of liquid biopsy is that mutations detected in ccf-DNA are highly specific of cancer and can clearly identify circulating tumor DNA (ct-DNA). Ct-DNA was explored as a prognostic or predictive marker for cancer detection; the studies suggested potential clinical applications. The analysis of ct-DNA ranges in scale from single mutations to whole-genome analyses. Liquid biopsy has many advantages compared to conventional sampling methods. The latter is subject to procedural complications, difficulty in obtaining sufficient material of adequate quality for genomic profiling and sampling biases that arise from genetic heterogeneity. A liquid biopsy is also superior to the conventional monitoring methods namely tumor markers that often lack specificity and imaging which exposes patients to ionizing radiation and has limited resolution. Promising as it is ccf-DNA and ct-DNA assays need scrupulous standardization to overlap discrepancies in sensitivities across various studies. However, sample collection is convenient, minimally invasive, and it avoids the need for tumor tissue biopsies. Analyzes of ccf- DNA and ct-DNA may have the potential to complement or replace existing cancer tissue and blood biomarkers in the future.

Biography:

Stef Stienstra works internationally for several medical and biotech companies as Scientific Advisory Board Member and is also an active Reserve-Officer of the
Royal Dutch Navy in his rank as Commander (OF4). For the Dutch Armed Forces, he is CBRNe Specialist with focus on (micro) biological and chemical threats
and Medical- And Environmental Functional Specialist within the 1st CMI (Civil Military Interaction) Battalion of the Dutch Armed Forces. For Expertise France, he
is now managing an EU CBRN CoE public health project in West Africa. In his civilian position, he is at this moment developing with MT-Derm in Berlin (Germany)
a novel interdermal vaccination technology as well as a new therapy for cutaneous leishmaniasis for which he has won a Canadian Grand Challenge grant. With
Hemanua in Dublin (Ireland), he has developed an innovative blood separation unit, which is also suitable to produce convalescent plasma for Ebola virus disease
therapy. He has finished both his studies in Medicine and in Biochemistry in the Netherlands with a Doctorate and has extensive practical experience in cell biology,
immuno-haematology, infectious diseases, biodefense and transfusion medicine.

Abstract:

Sharing security threat information is a challenge for governments and their agencies. Especially in biotechnology and microbiology the agencies do not know how to classify or to disclose collected information on potential bio-threats. There is vague border between man-made and natural biological threats. An example is the several month delay of the publication of research on the transmissibility of H5N1 avian influenza virus in the leading scientific journal Science by researchers of the Erasmus Medical Centre in Rotterdam, The Netherlands. The publication was delayed in 2012 by several months due to the fact that various organizations first wanted to investigate whether the details could be misused by malicious individuals. In the study the researchers show that only a small number of mutations were necessary to change the H5N1 virus so that it can spread through the respiratory system between mammals. This implies that the risk of a H5N1 pandemic cannot be ruled out. On the other hand, this information can be used to develop new therapies and/or vaccines for influenza. It gives also insight into the disease mechanism, which helps in the prevention. The same arguments are valid for therapeutic antibodies, like the antibodies, which are developed to treat anthrax. They have an extreme high affinity for the lethal factors of the bacterium and stop the disease, but the same antibodies could be misused to select the most pathogenic strains. Micro-organisms have from nature itself the capacity to reorganise and change their pathogenicity, which could lead to a pandemic spread of a disease. But if the disease is too infectious and too deadly, like some stains of Ebola Virus are, the lethality will be locally limited. But if the incubation time is longer in a certain strain of an Ebola virus, the risks on epidemics and even a pandemic is much higher. The knowledge of these natural mutation mechanisms could be misused to weaponize micro-organisms. It enables the engineering of the lethality like it is done with some anthrax strains. Are these laboratory techniques considered as public science or should it be classified? Academics want to publish and to share information for the progress of science and to find useful applications. The Rotterdam scientists were really annoyed when their research was blocked for publication and feared that other groups would be first in publishing a part of their obtained experimental results. Biosafety is already common practice in micro-biology, but biosecurity is often still questionable. A ‘Code of Conduct’, like the Dutch Academy of Science has developed, would help; especially for the so-called insider risk. Educational programs for the identification and assessment of risks and threats to security have to be developed to give scientists bio-threat awareness and for government officials to rationalize the real threat, without damaging the progress of science.

Biography:

Abstract:

Biography:

Deanna Mulvihill has her expertise in evaluation and passion for improving the health and wellbeing. Her open and contextual evaluation model based on responsive constructivists creates new pathways for improving healthcare. She has built this model after years of experience in research, evaluation, teaching, and administration both in hospital and education institutions. The foundation is based on fourth-generation evaluation (Guba & Lincoln, 1989) which is a methodology that utilizes the previous generations of evaluation: measurement, description and judgment. It allows for value-pluralism. This approach is responsive to all stakeholders and has a different way of focusing.

Abstract:

2014,17,01, an Editorial entitled “Planetary viral extension” underlined the insufficient attention of Occidental Countries to the 20 EBOLA epidemics within 30 years, with 9936 cases and 4877 deaths. Guinea, Liberia, Sierra Leone were the most contaminated populations. Starting in Guinea WHO announced 2000 deaths. A French investigation published in 2007 had described a blaze-off epidemics only in 1995 in Kinshasa West with 250 deaths. Since then a brutal development of the disease extremely contagious has gained a rapid geographical extension in all Sub-Saharan Africa, Zaire, Soudan as well as West African countries. A worldwide interest in the disease (the journal TIME in 2014 “now arriving the deadly Ebola virus lands in America” (death was waiting for the traveler). Four major analyzes: (a) Epidemiology: including local surveillance, containment measures, WHO and journals of instant information. (b) Measures Since 2007: CDC-Mobile laboratories, surveillance of suspects or alerts or probable  (febrile or hemorrhagic or deaths cases) (immediately notified). (c) The office of “rumors” (news) (WHO: gloves, javel, mosquitos). Ebola is transmitted directly by contact, imposing the “salut EBOLA” (EBOLA fistful). (d) Funerals major source of contamination with traditional cleaning, embalms in close contact with the body and family members. Containment, surveillance, education, hygiene, medical personnel are current. WHO “Staff at the  outbreak sites see evidence that the nimbers of reported cases and deaths underestimate the magnitude of the outbreak.”

Biography:

Dr. Ananda, K. J. has completed PhD in Veterinary Parasitology at the age of 30 years from Veteinary College, UAS, Bangalore, Karnataka, India & rendered 12 years of service in teaching and research, specialized in Immunological and Molecular Diagnosis of Parasitic diseases. Presently working as Associate Professor & Guided four PG students & bestowed with Best Research Paper and poster award in National Conferences & published more than 45 research papers in both International & National Journals. He was the recipient of University gold medal for Ph.D and handled 05 research project and presently with two extramural research projects.

Abstract:

Coccidian parasites are known to infect a wide variety of animals, including humans, birds and livestock. They are usually species-specific, but the well-known exceptions are toxoplasmosis caused by Toxoplasma gondii and cryptosporidiosis caused by Cryptosporidium parvum. The zoonotic coccidian parasites known to cause disease in humans belong to the genus Cystisospora, Cryptosporidium, Toxoplasma and Sarcocystis respectively.

Cystisospora belli is the only species of Cystisospora that infects man and is frequently responsible for “traveller’s diarrhea”. C. belli is found throughout the world but is more common in tropical and subtropical regions. This disease is typically mild in healthy individuals but can be life threatening in people who are young or immunodepressed. Cystisosporosis was largely ignored until its recent emergence as one of the opportunistic infections affecting AIDS patients.

Toxoplasmosis is an opportunistic infection in humans caused by protozoan parasite Toxoplasma gondii, widespread globally and responsible for serious complications in individuals with impaired immune defences as well as congenitally infected infants. The high prevalence rate in some parts of the world coupled with the current drug treatments that trigger hypersensitivity reactions makes the development of immunotherapeutic interventions a highly important research priority. Immunotherapeutic strategies could either be a vaccine which would confer a pre-emptive immunity to infection, or passive immunization in case of recurrent clinical diseases. As the severity of clinical manifestations is often greater in developing nations, the development of well-tolerated and safe immunotherapeutic becomes not only a scientific pursuit, but a humanitarian enterprise. In the last few years, much progress has been made in vaccine research with new antigens, novel adjuvants, and innovative vaccine delivery such as nanoparticles and antigen encapsulations.

Cryptosporidium is increasingly gaining attention as a human and an animal pathogen mainly due to its dominant involvement in worldwide waterborne outbreaks. Ingestion of oocysts can cause gastrointestinal disease in immunocompetent and immunosuppressed human patients and those working with animals, including farmers and veterinarians, are considered to be at increased risk. Efforts to minimise transmission in people handling infected animals should include instruction regarding, and rigorous attention to, hygiene, protective clothing and efforts to disinfect contaminated areas.  

Sarcocystis spp. have indirect life cycle with an intestinal infections occur in the definitive host, and tissue invasion is seen in the intermediate host. Three species viz., Sarcocystis hominis, S. heydorni (intermediate hosts: cattle) and S. suihominis (intermediate hosts: pig) have been identified where humans serve as definitive hosts and get infected by ingesting raw or undercooked beef and pork respectively. Although others may exist, till now only S. nesbitti has been identified in humans serving as intermediate hosts based on 18S ribosomal DNA (rDNA) sequence analysis. Though the life cycle of S. nesbitti remains unknown, this zoonosis is linked to ingestion of food and water contaminated with the sporocysts of this species.

Biography:

Elias El Haddad is a Freelancer and Owner of  El Haddad Dental Clinic in Turin, Italy. He is a Scientific Manager of the Periodontology Department U.O.A of Odontostomatology Complex Structure of Dentistry and Maxillofacial Surgery, Martini Hospital, Turin. He completed his Graduation in Medicine and General Surgery at University of Turin; specialized in General Pathology at University of Turin and; completed Post-graduation in Implantology and Periodontics at the New York University. He dedicated himself to Implantology since 1988 following numerous courses in Italy and abroad.

Abstract:

A reduced or non-existent keratinized mucosa around the natural teeth and around the implants can promote inflammation of the mucous membrane plaque, the risk of bone resorption, the soft tissue dehiscence and also the loss of clinical attack. Managing patient requests with success that meets function and esthetics in reconstructive periodontology is among the biggest challenges in dentistry. The restoration of the keratinized tissue around the natural teeth is a technique that guarantees excellent functional and aesthetic results, in the long term very predictable. Despite the controversies, which still exist today in the literature, the presence of a good quality and quantity of keratinized tissue around the implants is necessary to prevent inflammatory phenomena such as mucositis and periimplantitis. In this report the simplest surgical techniques will be examined. Safe clinical outcome at a distance, combined with various clinical cases of rehabilitations on natural elements and implants.    

Biography:

K Pani Prasad is currently working as a Principal Scientist in Aquatic Environment and Health Management Division, Central Institute of Fisheries Education, India.

Abstract:

Diseases are recognized as one of the major constraints to global aquaculture production and are responsible for the severe\r\nimpact on both the economic and socio-economic development in many countries of the world. One of the greatest\r\nchallenges and opportunities for expansion of sustainable aquaculture has been proven to be in managing the health of aquatic\r\norganisms. Eff ective disease control is paramount within aquatic farming systems to stop the spread of infectious pathogens.\r\nAny successful health management programme should monitor the health status of the fi sh, identify and manage risks to fi sh\r\nhealth, reduce exposure to or spread of pathogens and manage the use of antibiotics/ chemicals. Th e success of any farm operation\r\ndepends on health management systems implemented. Th e rapid detection of pathogens in infected fi sh, both clinically and\r\nsub-clinically, is desirable for eff ective health management in aquaculture. Traditional bacteriology, virology, parasitology and\r\nmycology are appropriate for detection of common, easily cultured pathogens; however, for many pathogens these methods\r\ncan be expensive, time-consuming and might not lead to defi nitive diagnosis being mad, even when complemented with\r\nhistological evidence. In addition to the traditional techniques used in fi sh disease diagnostics, a few modern methods like\r\nLAMP, Real time PCR, Lateral fl ow, micro technologies which mainly include bio-barcode assay are highlights. Also, in vaccine\r\nand immunodiagnostic kit development, surface display technique and egg yolk antibody production are emerging in fi sh\r\nhealth management and diagnosis.

Biography:

Abstract:

Biography:

Arpitha Parthasarathy completed her PhD in Biomedical Sciences from Aravind Eye Hospitals, India and Postdoc from National Institutes of health, Maryland. She\r\nhad her short Postdoctoral stints at GWU and University. She has published in many peer reviewed ophthalmic journals and is now the “Director of Translational and\r\nMolecular Biology Research” at Plasma Medicine Life Sciences and heads the Translational and Molecular Biology Division of Jerome Canady Research Institute for advanced Biological and Technical Sciences, USA.

Abstract:

Retinoblastoma (RB1) is a progressive cancer which mainly occurs in children, which is caused by genetic or epigenetic\r\nalterations that lead to inactivation of both alleles of the RB1 gene. Retinoblastoma accounts for 11% of cancer in the\r\nfirst year of life. Recent studies have suggested the use of intravitreal therapy using VEGF as a photodynamic therapy,\r\nhowever, chemoprophylaxis for tumor treatment regimen still seems to be the best accepted approach for tumor bearing\r\nretinoblastoma. Recent studies have suggested that mRNA-365 targets cyclin dependent kinase 6/4 induces tumor progression\r\nand yet chemotherapeutic intervention has been the only available method as therapy. We report for the first time in the field\r\nof ocular tumors, that the cold atmospheric plasma induces an altered energy metabolism via redox potential and induces\r\nspecific receptors like TRAIL-R1 to be elevated causing cell death of retinoblastoma cells in vitro. The elevated expression\r\nof TNF-associated receptor TRAIL-R1 induces DNA nick and apoptosis possibly via p53 and Nf-kb pathway. The specificity\r\nand selectivity of tumor cell death/apoptosis with the use of cold atmospheric plasma suggests that a combination of cold atmospheric plasma along with reduced doses of chemotherapeutic drug will highlight the significance in the treatments of ocular tumors.

Biography:

Weiqiu Chen received his BS and PhD degrees from Zhejiang University in 1990 and 1996, respectively. He worked as a postdoctoral Research Associate at The University of Tokyo during 1997-1999. He was promoted as an Associate Professor in 1999 and a full Professor in 2000. He has engaged himself in the mechanics
of smart materials/structures and vibration/waves in structures for over twenty years. He has co-authored over 350 peer reviewed journal articles and three monographs. He now serves as the Editorial Member/Associate Editor in chief of 12 academic journals including Mechanics of Advanced Materials and Structures, Journal of Thermal Stresses and Composite Structures.

Abstract:

Soft electroactive materials can deform to a large extent in a reversible way under mechanical or electrical loading. This unique ability makes them very attractive to be the material candidates for designing smart and tunable devices, structures and systems. We will report some recent advances in tunable soft Phononic Crystals (PCs) in which waves can be manipulated according to the application purpose. In particular, attention will be paid to a simple one-dimensional soft PC cylinder made of dielectric elastomer. A series of mechanically negligible soft electrodes are placed periodically along the dielectric elastomer cylinder and hence the material is actually uniform in the undeformed state as well as in the uniformly pre-stretched state subjected to a static axial force only. Th e periodicity of the structure that is required for a PC is acquired via two diff erent loading paths. In the fi rst path, we fi x the ongitudinal stretch and then apply an electric voltage over any two neighboring electrodes. In the second path, the axial force is kept unchanged and then the voltage is applied. Th e outstanding performance regarding
the band gap (BG) property of the soft dielectric PC is well demonstrated through the comparison with the conventional design
adopting the hard piezoelectric material. We also illustrate that the snap-through instability of the axially free PC cylinder made of a generalized Gent material may be used to trigger a sharp transition  in the BGs.

Biography:

Dr. Alvarez Cuenca is a Professor of Chemical Engineering and Director of the Water Technologies Laboratory at Ryerson University (Toronto, Canada). He holds a B.Eng (Chemical Engineering) from the Universidad Politecnica de Madrid, and an M.Sc. and a Ph.D. in Physics and Chemical Engineering respectively from the University of Western Ontario (Canada). Manuel adds to his curriculum over 15 years of industrial experience with multinational corporations in the areas of fluidized bed reactors, bioreactor design, water treatment and clean power generation. In 2002, he founded Ecotechnos Inc., a company devoted to the design and construction of advanced bioreactors for the treatment of industrial watewater including nitrogen and phosphorous removal. He is an active consultant for both, governments and the private sector in Canada, Spain and Iberoamerica in the areas of water treatment, and energy. His academic record spans over three decades with universities in Europe, Canada, and South America, including Ryerson University, U. of Western Ontario, U of Waterloo, U. of Guelph, U of Windsor, U.Politécnica de Madrid ( Spain), Universidad Nacional de Colombia (Colombia), U de Cartagena de Indias (Colombia), Corporacion Universitaria de la Costa (Colombia).

E-mail: ecotechnos@rogers.com, mcuenca@ryerson.ca

Abstract:

The availability of water quality and quantity are facing an unprecedented crisis created by explosive demographic growth and overuse. Hence urban and industrial scarcity, limited construction surface and increasing chemical complexity of contaminants, like nutrients, microplastics, endocrine disruptors, etc. Contaminated water is defined here as water not suited for direct human consumption or industrial utilization whose composition has deleterious effects on either human health or the environment. The recovery of water for human utilization presents an unprecedented challenge. That recovery demands effective reactors, of reduced power consumption, demanding little construction surface for retrofitting and refurbishing.

Historical records show that contaminated water has been treated to achieve potability for thousands of years. The treatment was only physical (sand filtration) but in more recent times contaminated water has been treated chemically and biologically, or the physical treatment has become more complex.

Planar bioreactors (Often called aeration tanks) of circular or rectangular cross section have been the first choice for water engineers. Furthermore, in the last few decades, the kinetics of the processes, the control and instrumentation, and the reactor design of the biochemical reactors involved have become more precise and sophisticated.

The purpose of this presentation is to describe the STAR process including the application of the Multistage Vertical Bioreactor (USA Patent 8,585,900 B2) to the elimination of nutrients in contaminated water.
 

This bioreactor developed in the Department of Chemical Engineering of Ryerson University (Canada), offers powerful features associated to its performance removal, construction materials, reduced planar construction space, geometry and modular configuration. The simultaneous removal of both ammonia and total phosphorous exceeds 93 % for each contaminant. Two abundant microbial groups Saprospirasae (unidentified species) and Zoogloea are responsible for the simultaneous removal of ammonia and total phosphorous in the process
 

Biography:

Per Jensen is professor of theoretical chemistry at the University of Wuppertal, Germany. His research interests lie in the border area between high-resolution molecular spectroscopy and quantum chemistry. He develops and applies methods for the accurate simulation of rotation-vibration spectra of small molecules, mostly of astrochemical and/or atmospheric interest. He is particularly interested in the application of molecular symmetry to facilitate the solution of nuclear-motion problems. Recently, he has worked extensively on interactions between electronic states (the Renner effect), the characterization of rovibrational energy clusters at high rotational excitation, and extremely flexible (structureless) molecules. He is author or co-author of about 200 publications.

Abstract:

Traditionally, molecules are theoretically described as near-static structures rotating in space. Vibrational motion causing small structural deformations induces a perturbative treatment of the rotation-vibration interaction. This treatment fails in highly flexible molecules, where all vibrational motions have amplitudes comparable in size to the linear dimensions of the molecule. An example is protonated methane (CH₅⁺). For these molecules, customary theory fails to simulate reliably even the low-energy spectrum. Within the traditional view of rotation and vibration being near-separable, rotational and vibrational wavefunctions are symmetry classified separately in the molecular symmetry (MS) group. All MS groups discussed so far are isomorphic to subgroups of the special orthogonal group in three dimensions SO(3). This leads to a group theoretical foundation of the technique of equivalent rotations. The group G₂₄₀ (the MS group of protonated methane) represents, to the best of our knowledge, the first example of an MS group which is not isomorphic to a subgroup of SO(3). Because of this, a separate symmetry classification of vibrational and rotational wavefunctions becomes impossible in this MS group, consistent with the fact that a decoupling of vibrational and rotational motion is impossible. The talk will discuss the consequences of this and propose an alternative description making use of the fact that G₂₄₀ and SO(3) are both subgroups of the group SO(5) of rotations in five-dimensional space. We take SO(5) to be a near-symmetry group for CH₅⁺ and develop a theoretical model that successfully explains recent experimental observations of rotation-vibration transitions in cold CH₅⁺. Two of the vibrational degrees of freedom are essentially free and, in an initial approximation, these vibrations are combined with the “usual” rotation in 3D space with the resulting motion being viewed as free rotation in 5D space, consistent with the symmetry group SO(5).

Figure 1: The effect of the proton permutation (15432) on a CH₅⁺ ion. It rotates the quantization axis z and so the customary technique of equivalent rotations cannot be applied.

Biography:

Amr M. Mohamed has completed his PhD at the age of 35 years from University of Nebraska\r\nMedical Center, USA at 2004 He worked as associate professor of molecular diagnostics of\r\ninfectious diseases at School of veterinary medicine, Assiut University, Egypt. Currently he is a\r\nfull professor of Laboratory Medicine at Umm Al-Qura University, KSA. He is the director of\r\nMolecular Diagnostic Research Laboratory at the Central Laboratories of Collage of Applied\r\nMedical Sciences, Umm Al-Qura University. He has published more than 20 papers in reputed\r\njournals and has been serving as an editorial board member of many reputed Journals.

Abstract:

Tuberculosis (TB), the second highest cause of death from infectious diseases worldwide, is a major global health problem. Infection with strains of Mycobacterium tuberculosis complex (MTBC), the causative agent of TB, is responsible for approximately 1.4 million deaths annually. TB remains a major cause of morbidity and mortality throughout the world with major challenges facing the global effort for controlling the disease. One of the major challenges is the worldwide emergence of drug resistant strains of MTB. The greatest challenge that still facing TB-patient is that the organisms, through selection of mycobacterial mutants that result from spontaneous chromosomal alterations, become resistant to one or more of the standard anti-TB drugs. The efforts for TB control and treatment were critically hindered by the emergence of multidrug-resistance. Multidrug-resistance (MDR) is defined as the resistance of the bacillary strains to at least isoniazid (INH) and rifampicin (RMP), the two key first-line anti-tuberculosis drugs. Nevertheless, MDR-TB is not incurable, a fluoroquinolone [e.g. levofloxacin (Lfx), moxifloxacin (Mfx), ofloxacin (Ofx)], if used properly alongside other second-line injectable drugs [e.g. capreomycin (Cm), amikacin (Am) or kanamycin (Km)] could cure the majority of MDR-TB patients; with a low risk of relapse in long-term follow up. However, the challenge became even worse by the recent emergence of the extensively drug-resistant (XDR) bacillary strains. The term XDR-TB used to describe a severe form of disease, which is a case of MDR-TB with additional bacillary resistance to any of the fluoroquinolone and at least one of three second-line injectable drugs: Cm, Km and Am. Recently, the WHO estimated 650.000 cases (including 150,000 deaths) of MDR-TB with an estimated XDR-TB rate of 9% in 2010. The emergence of multidrug-resistant tuberculosis (MDR-TB), due to clinical, biological, or social factors, is now estimated to account for half a million new cases each year. The treatment of MDR-TB requires prolonged and expensive chemotherapy using second-line drugs of heightened toxicity. WHO have recently reported the highest global levels of drug resistance ever documented with 3.6% of new TB patients and 20% of previously treated cases having MDR-TB. With regard to XDR-TB, WHO in its 2011 report estimated 650.000 cases (including 150,000 deaths) of MDR-TB with an estimated XDR-TB rate of 9% in 2010. More recently, The WHO report of 2013 revealed that 92 countries had reported XDR-TB globally by the end of 2012. \r\nIn conclusion, the worldwide emergence of MDR or XDR strains of MTBC pose a serious challenge for global TB control and make successful treatment difficult or even impossible. The aim of the current talk is to through the light on the most recent WHO figures and to discuss the current methods and tools for diagnosis and treatment of tuberculosis and to elaborate the recommended preventive measurements for successful control of the global drug resistant tuberculosis. \r\n

Biography:

Abstract:

Biography:

Dr. Vinit Wankhede is a Consultant Pediatric Neurologist and Epileptology’s, currently practicing in Nagpur City in the state of Maharashtra, India. He has done his MBBS from Government Medical College and Hospital, Nagpur. He completed his DCH from BJ Medical College, Pune and DNB from Choithram Hospital & Research Centre, Indore. He underwent fellowship training in Pediatric Neurology & epilepsy at Bharati Hospital & Research Centre, Pune. He received honors and gold medals in his master's educations from Maharashtra University of Health Sciences and also from Neurology chapter of Indian Academy of Pediatrics for 1st rank in India. Currently, he is editor of the Indian Journal of pediatric neurology and has organized various Pediatric Neurology seminars, workshops, and conferences.

Abstract:

Introduction: Pilot studies and results of a meta-analysis of randomized controlled trials in neonates with ischemic encephalopathy have reported that therapeutic hypothermia decreases the mortality and improves the neurological outcome of neonates with perinatal asphyxia. However as servo controlled equipment to deliver therapeutic hypothermia is extremely expensive, we assessed the low-cost delivery method using cool packs. We also studied the problems and complications associated with this technique of maintaining sustained hypothermia.

Materials and methods: This was a prospective observational study conducted at NICU after ethical committee clearance. Inclusion criteria were 1.Gestational age > 36wks, 2.Birth weight > 2 kg, 3.Age < 6 hours, 4. Documented moderate to severe birth asphyxia defined in the study protocol. After obtaining informed consent from the parents, the neonates underwent cooling by using ice packs. The core temperature of the baby was recorded by inserting an oesophageal probe. All supportive management was started as per our NICU protocol. The core temperature of the neonates was monitored serially till the total period of 84 hours. Serial laboratories were obtained at the time specified by the protocol. After 72 hrs, the neonates were rewarmed slowly to a normal core temperature by 0.5°C every hour. Thereafter detailed daily examination was noted till discharge.

Results: Of 32 neonates admitted with perinatal asphyxia in1 year study period, only 6 were eligible for therapeutic hypothermia. The mean time taken to achieve target oesophageal temperature in 6 patients who underwent therapeutic hypothermia was 90 minutes. Mean oesophageal temperature was 33.75˚C and could be maintained for 72 hours with the use of cool packs. Rewarming phase took mean of 6 hours 45 min± 55min. Adverse events observed during cooling were sepsis, coagulopathy, hyponatremia, hypotension and abnormal renal function.

Conclusion: We have demonstrated that it is feasible to deliver therapeutic hypothermia using a low-cost model of room temperature modulation and ice packs in resource-limited settings. However, the adverse events may limit its use in resource-limited settings.

Biography:

Abstract:

Nanoparticle-based drug delivery systems can potentially overcome several barriers to drug delivery, reduce toxicity to the patient, and thus improve therapeutic outcomes. Over time, nanoparticles have undergone evolution from simple to more complex systems, yet the nanoparticle formulations developed as “nanomedicine” for clinical use remain quite simple. Our laboratory research has shown that simple nanoparticle formulations, developed with a solid rationale, are very effective in treating complex conditions. This overview will describe nanoparticles that are straightforward in design yet effective in treating complex diseases in animal models. One example is a formulation that successfully treats bone metastasis, considered the primary cause of death in many types of cancers but more particularly in prostate and breast cancers. A second example is a formulation that effectively modifies the after-effects of stroke. This presentation will also define the challenges in moving complex nanoparticles through regulatory pathways and the scale-up process toward eventual commercialization.

Biography:

Ron Hart has done his B.S. in University of Connecticut, Storrs, CT and Ph.D.in University of Michigan, Ann Arbor, MI. He has done his postdoctoral training under William Folk, advisor from University of Michigan, Ann Arbor, MI and Joseph Nevins, advisor from Rockefeller University, New York, NY. He is the Director of Human Genetics Institute of New Jersey Stem Cell Program and Co-Chair in Rutgers University Institutional Biosafety Committee.

Abstract:

Biography:

Doctoral degree of Moscow State university. He worked as Senior researcher Armenian Institute of Agriculture and Technological Institute of Amino Acids of USSR,director of Armenian Institute of Biotechnology, director of Yerevan Vitamin plantand deputy director of Nairit Chloroprene Rubber plant. Sole founder of Research &Industry Centre of Photosynthesizing Organisms, Feed Additives & Physiologically Active Compounds; Expert of EU Horizon 2020, ERA.NET and International Cooperationprograms and Council of Chemistry and Petrochemistry of CIS countries. AcademicMember of the Greece ATINER Academia, Member of American Chemical Society and Society of Chemical Industry (USA),  Member of Editorial Boards of journals:“Journal of Chemical, Environmental and Biological Engineering" (USA),SM Journal of Environmental Chemical Engineering" (USA) and Modern Management Forum (Singapore). Laureate of “The International Presidents Award for Iconic Achievement” and “Top 100 Professionals” (IBC, England), "The Albert Einstein Award for Excellence" (Top 50 Geniuses of World, ABI, USA), Marquis Who's Who “2017 Albert Nelson Marquis Lifetime Achievement Award” (USA), awards of the Armenia and former USSR

Abstract:

Biography:

C Kadlec obtained her PhD in Plasma Physics from the University of Orleans, France. She works as a Researcher in the Institute of Physics in Prague, Czech Republic in the field of THz spectroscopy, where she is considered as an expert in thin films. She is a co-author of more than 60 publications.

Abstract:

We investigate thin superconducting NbN films with various thicknesses by time-resolved terahertz spectroscopy. In agreement with previous reports, the equilibrium THz conductivity can be described by the BCS theory. Upon strong photoexcitation by femtosecond laser pulses, when the superconducting state is completely broken, the recovery dynamics occurs by a growth of initially spherical isolated superconducting islands in the normal-state environment. These islands subsequently merge towards a nearly percolated superconducting network. The recovery process is accompanied by a shift in the conductivity spectral weight, indicating a departure from the BCS character of the density of electron states in these islands. While the superconductivity recovers on the hundreds-picosecond time scale, the properties characterizing the superconducting state (such as the gap width and the density of states) recover much more slowly, at least on the nanosecond time scale.

Biography:

Sheikh Jan M is the Consultant Cardiologist (MD. DNB –Senior Resident Cardiology,Batra Hospital and Medical Research centre, New Delhi, India.

Abstract:

Background: An early diagnosis of myocardial infarction is highly important in the emergency department (ED). It facilitates rapid decision making and treatment and therefore improves the outcome in patients presenting with symptoms of chest pain. 

Aims and Objectives: To study diagnostic utility of new point of care high sensitive troponin-I assay in early diagnosis of acute myocardial infarction in patients presenting with acute chest pain.

Materials and methods: Forty six consecutive patients of acute onset chest pain who presented to our cardiac emergency department within three hours of symptom onset were enrolled for study.POC Hs Trop-I test was done on admission (0 hour), and after 3 hours if initial test result was negative. Quantitative troponin I (Q-Trop I) lab assay was done on admission (0 hour), 3 hours and 6 hours after admission. Six hour Q-Trop I assay was taken as gold standard for the initial diagnosis of AMI. The final adjudicated diagnosis of AMI was based on a composite of ECG changes (new ST segment or T wave changes, new onset LBBB), Troponin results, Echocardiography (new wall motion abnormality), angiographic findings (detection of a culprit lesion) and final chart review of observations made.

Results: Comparing the results of POC Hs Trop I results at 0 hour with the gold standard test we found the sensitivity of 97%, specificity of 100%, positive predictive value (PPV) of 100% and negative predictive value (NPV) of 92.3%. Sensitivity of POC Hs Trop I at 3 hours was better than POC Hs Trop I at 0 hour (97 vs. 100%) and equal to gold standard i.e. 100 %.Specificity, PPV and NPV are 100% for POC Hs Trop I at 1 hour.

Conclusion: High sensitive Trop I test is rapid and reliable method to diagnose and exclude acute myocardial infarction in patients presenting with acute onset chest pain to our EmergencyDepartments.

Biography:

Abstract:

Biography:

Shavonne Massey is an Attending Physician in the Departments of Neurology and Pediatrics at The Children’s Hospital of Philadelphia and The Perelman School of Medicine at The University of Pennsylvania in Philadelphia, PA. She is a Pediatric Epileptologist with clinical and research interests in the management of brain injured neonates. Within this neonatal population, her specific interests are the use and value of the electroencephalogram in the diagnosis of seizures, development of neurophysiologic biomarkers for brain injury and outcomes, management of seizures, and development of predictive strategies and modeling for acute and chronic outcomes in this population.

Abstract:

Over 800,000 neonates suffer brain injury yearly and seizures are the most common clinical manifestation. Seizures are common during the neonatal period due to age-dependent mechanisms that favor excitability in the immature brain. There are a myriad of potential causes for neonatal seizures, but acute causes, such as hypoxic ischemic encephalopathy, stroke, hemorrhage, and infection, are most common, accounting for up to 80% of cases. The recognition of neonatal seizures is important because seizures are associated with unfavorable acute and chronic outcomes. In the past, seizures were diagnosed clinically, but with growing recognition of the very high subclinical seizure burden that exists in the neonatal population, the electroencephalogram (EEG) is now the gold standard for diagnosing and managing neonates at high risk for seizure occurrence. With the use of EEG, more neonates with seizures are identified bringing considerations in the management of neonatal seizures to the forefront of neonatal care. While there is a growing body of literature on the occurrence and diagnosis of neonatal seizures, many questions remain about the best ways to manage neonatal seizures. Developing best practices for the management of neonatal seizures is of paramount importance given that the mere presence of neonatal seizures can worsen the neurodevelopmental trajectory. This session will review the epidemiology and etiologies of neonatal seizures, as well as the diagnosis of neonatal seizures and the important role of the EEG in accurately diagnosing seizures. The session will also review outcomes data from basic and clinical models of neonatal seizures. The majority of the session will focus on specific considerations in the treatment of neonatal seizures, including when to treat seizures, the mechanisms and data supporting the use of specific antiseizure medications, novel antiseizure medications currently under investigation, and the presence and effect of variability in the treatment of neonatal seizures

Biography:

CEO & Founder - Biotechnology and Regenerative Medicine at RegenerAge International ™ (www.regenerage.clinic) VP of International Clinical Development for Bioquark, Inc.

(www.bioquark.com) Chief Clinical Officer at ReAnima™ Advanced Biosciences (www.reanima.tech) Westhill University School of Medicine.

Mexico Advance Fellow by the American Board of AntiAging and Regenerative Medicine (A4M)

Visiting scholar at University of North Carolina at Chapel Hill (Dermatology) Fellow in Stem Cell Medicine by the American Academy of Anti-Aging Medicine and University of South Florida

Abstract:

As it has been previously demonstrated that coelectroporation of Xenopus laevis frog oocytes with normal cells and cancerous cell lines induces the expression of pluripotency markers, and in experimental murine model studies that mRNA extract (Bioquantine® purified from intra- and extra-oocyte liquid phases of electroporated oocytes) showed potential as a treatment for a wide range of conditions as Squint, Spinal Cord Injury (SCI) and Cerebral Palsy among others. The current study observed beneficial changes with Bioquantine® administration in a patient with a severe SCI. Pluripotent stem cells have therapeutic and regenerative potential in clinical situations CNS disorders even cancer.2-3- 7 One method of reprogramming somatic cells into pluripotent stem cells is to expose them to extracts prepared from Xenopus laevis oocytes1 We showed previously that coelectroporation of Xenopus laevis frog oocytes; with normal cells and cancerous cells lines, induces expression of markers of pluripotency.4 We also observed therapeutic effects of treatment with a purified extract (Bioquantine) of intra- and extra-oocyte liquid phases derived from electroporated X. laevis oocytes, on experimentally induced pathologies including murine models of melanoma, traumatic brain injury, and experimental skin wrinkling induced by squalenemonohydroperoxide (Paylian et al, 2016).

The positive human findings for Spinal Cord Injury, and Cerebral Palsy with the results from previous animal studies with experimental models of traumatic brain injury, respectively (Paylian et al, 2016). Because of ethical reasons, legal restrictions, and a limited numbers of patients, we were able to treat only a very small number of patients. These results indicate that Bioquantine ® may be safe and well tolerated for use in humans, and deserves further study in a range of degenerative disorders. We propose that the mechanism of action of Bioquantine® in these various diseases derives from its unique pharmacology and combinatorial reprogramming properties. In conclusion, these preliminary findings suggest that Bioquantine is safe and well tolerated on patients with Cerebral Palsy and- Spinal Cord Injury, among others. In addition to the regenerative therapy and due to the patient condition, we decided to include the Restore- Sensor SureScan5-6 . Based on the of electrical stimulation for rehabilitation and regeneration after spinal cord injury published by Hamid and MacEwan 8-9 , we designed an improved delivery method for the in situ application of MSCs and Bioquantine® in combination with the RestoreSensor® SureScan® Conclusions: To the present day the patient who suffered a total section of spinal cord at T12-L1 shows an improvement in sensitivity, strength in striated muscle and smooth muscle connection, 11 months after the first therapy of cell regeneration and 3 month after the placement of RestoreSensor ® at the level of the lesion, the patient with a complete medullary section shows an evident improvement on his therapy of physical rehabilitation on crawling from front to back by himself and standing on his feet for the first time and showing a progressively important functionality on the gluteal and legs sensitivity

Biography:

Daniel Bauer is internationally revered as the Successor to the legendary escape artist Harry Houdini and globally respected as a 12-year warrior and survivor living with\r\nHIV/AIDS. Through heart-breaking loss, such as burying his baby brother who passed from AIDS-related complications, to conquering impossible moments of rare survival,\r\nhe has gracefully triumphed to once again pursing his dreams. He is one of the most requested motivational public speakers and entertainers who continues to present\r\nhighly engaging educational experiences and spectacularly, life-changing theatrical productions to tens of thousands annually (adolescents, healthcare professionals and\r\nmainstream communities &audiences at-large) focusing on topics such as living with HIV/AIDS, prevention, reversing HIV/AIDS-related man-made stigma and so much\r\nmore. He is the current active celebrity voice and face of JustGetTested.com. He continues to work tirelessly to promote equality for all living with and/or affected by the\r\nglobal HIV/AIDS pandemic. His work as both an escape artist and speaker have been featured on national television networks [NBC, CBS, ABC and FOX], international\r\nprint/radio media (i.e. poz.com/blogs, positivelite.com, NPR Radio, Poz I Am Radio Show), international theatrical stages including New York City off-Broadway; and\r\nhas been highlighted at internationally revered events such as The OMICS Group 2013 International HIV/STI Conference, The National Healthy Living Summit, 2012\r\nInternational AIDS Conference (AIDS Reunion Program, Washington, D.C.), The 2013 University of Minnesota African Student Association Red Spots Gala, and The Texas\r\nState-wide HIV/HEI Conference.

Abstract:

On World AIDS Day, this keynote forum will invite attendees down an emotionally empowering and engaging journey to\r\nremember those who have dedicated their lives to fighting the global HIV/AIDS epidemic. This time is to reflect on the\r\nhistorical milestones, to remember those who we have lost, and to celebrate those who are still standing tall to make a difference in eradicating both the virus and stigma. Attendees will walk away with a comprehensive reminder of the history of HIV/AIDSaround the world.

Biography:

Abstract:

Biography:

Emmanuel Mukwevho has completed his PhD in 2010 from University of Cape Town, South Africa in Anatomy and Cell Biology. He is an Associate Professor of\r\nBiochemistry at North West University, South Africa. He has published both nationally and intaernationally in reputed journals and his specialiality is in Obesity and\r\nDiabetes where he lead the Diabetes & Obesity Therapeutics Research group at North West University.

Abstract:

CaMKII regulates many pathways involved in the regulation of various cellular and molecular mechanisms that result\r\nin myriad health benefits. Exercise is a key activator of CaMKII, and shown to improve many functional activities in\r\nindividuals who exercise compared with those who do not exercise, however the mechanism involved not yet fully elucidated,\r\nwhich became the objective of this study.\r\nIn this study using rats, we investigated various lipids metabolism for both saturated and non-saturated fatty acids in\r\nrats that exercised, non-exercised and exercised+KN93 (CaMKII inhibitor). Lipids were analysed using GC×GC TOFMS.\r\nPalmitoleic acid and oleic acid which are monounsaturated fatty acids known to promote insulin sensitivity and improve\r\nglycaemic control were investigated. Levels of the exercise group showed ~2.0 fold increase compared with the non-exercise\r\n(control) group. Abolishing CaMKII activity by administration of KN93 significantly decreased exercise-induced Palmitoleic\r\nacid levels. Oleic acid levels of the exercise group were ~ 4.1 folds higher than the non-exercise group and followed the same\r\npattern as Palmitoleic acid.\r\nLauric acid is a saturated fatty acid, which increases fatty acid needed for better health. The exercise group showed ~ 8.7\r\nfold increase compared with the non-exercise group of Lauric acid. The exercise + KN93 group significantly reduced induction\r\nby ~2.5 fold compared with the exercise group. On the other hand, Myristic acid and palmitic acid which are saturated fatty\r\nacids known to increase risk factors of metabolic syndrome. The myristic acid level of the exercise group decreased by ~3.4\r\nfold compared with the control group, whereas the exercise + KN93 group significantly increased by ~4.3 compared with the\r\nexercise group.\r\nIn conclusion, CaMKII can reduce the risk factors of metabolic syndrome and type 2 diabetes.

Biography:

Aby J Mathew was part of the founding team of BioLife Solutions, Inc., and is a co-developer of BioLife’s biopreservation media solutions. He has been researching low-temperature biopreservation since 1994, and his studies contributed to the development of BioLife’s current commercial HypoThermosol® and CryoStor® product platforms and intellectual property foundation. He was BioLife’s first Director of Manufacturing, established BioLife’s initial quality system, and is currently Senior Vice President & Chief Technology Officer. He is a member of AABB, BEST Collaborative, ISCT, ARM, TERMIS, and the Society for Cryobiology. He is a member of the Board of Directors and the Advisory Panel of the Parent’s Guide to Cord Blood Foundation, the Scientifi c Advisory Board of HemaCare Corporation, the founding Board of Directors of the Cord Blood Association, the NIST-AMTech National Cell Manufacturing Consortium, and the California Institute for Regenerative Medicine (CIRM) Clinical Advisory Panel. 

Abstract:

Biography:

Abstract:

Biography:

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Biography:

Abstract:

Biography:

Joachim Maier studied Chemistry at the University of Saarbrücken, received his PhD in 1982 from the same university and completed his Habilitation at the University of Tübingen in 1988. He has lectured at the University of Tübingen, at Massachusetts Institute of Technology as a foreign Faculty Member, at the University of Graz as a Visiting Professor, and at the University of Stuttgart as an Honorary Professor. He is Past President of the International Society of Solid State Ionics. As Director of the Physical Chemistry Department (since 1991) of the Max Planck Institute for Solid State Research and Member of various national and international academies his concern is the conceptual understanding of chemical and electrochemical phenomena involving solids as well as their use in materials science. He has been listed as one of the most influential scientific minds (Thomson Reuters).

Abstract:

In loose terms chemistry is the chemistry of the perfect state (perfect crystallographic structure) plus chemistry of the excited state (defect structure). The latter is responsible for the electric transport and storage properties. In aqueous solutions this function is taken by H⁺ and OH^- ions as well as dissolved ions. In solids this role is carried out by point defects such as excess (interstitials) and lacking particles (vacancies). It is exactly the consideration of point defect chemistry which is necessary to understand and tune ionic transport phenomena in solids hence forming the bridge between chemistry and electric function. This picture also comprises the electronic transport enabled by excess electrons and electron holes. It is shown how the charge carrier chemistry can be understood, analyzed and varied as a function of stoichiometry and doping not only in the bulk but also at interfaces. Of special interest are size effects on the electronic and ionic carrier concentrations. These defect-chemical considerations directly translate into the electric function in batteries, fuel cells and photo-electrochemical devices. This does not only hold at or near equilibrium, also the kinetic performance depend on such issues. In addition to transport-related questions, the point defects are most relevant acid-base or redox-active centers and are thus of central significance, not only for transport, but also for reaction kinetics and catalysis. A selection of applied examples such as storage modes in batteries, reaction kinetics in fuel cells or transport effect in photo-perovskites will be addressed.

Biography:

Abstract:

Biography:

Ronald Naumann received Diploma as graduate engineer in 1993 from Fachhochschule Anhalt Bernburg; Germany. Before his military service, he received education as zoo technician from 1984 to 1986. He started his career as Manager for agriculture in estate Kaltenbrunn, Germany.In 1995 he joined Max Planck Institute of Biochemistry as Foreman and animal breeder in 1995. Over the years, Ronald had established mutiple successful transgenic facilities within Europe. He founded transgenic facilities at University of Manchester in 2001, at European Institute of Oncology, Italy in 2005, at University of Freiburg, Germany in 2011 and at University of Jena, Germany in 2015. Currently, Ronald is the Group Leader of Transgenic Core Facility at Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany since 2002.

Abstract:

Today, the mouse is a widely used animal model in the scientific community. The Transgenic Core Facility (TCF) at the MPI-CBG provides a centralized resource and stateof-the-art technology in production of Knock-Out (-IN) mice by injection or aggregation of embryonic stem cells into mouse embryos, and transgenic mice by injection of DNA or CRISPR into the cytoplasm or pronuclear of mouse zygotes. Our transgenic service facility generated about 70 mutant mouse lines per year. As backups in any cases, we use sperm freezing and embryo freezing to store all our mouse lines in safety conditions. We work very successful and efficient in full cost accounting. I would like talk about management, 3R's animal welfare, budget, animal and personal resources and the generating of mutant mice in a high health level (SPF). We show that using of fresh or frozen mouse embryos from breeding companies as donor for ES-cell injection is a flexible tool to provide customized projects. All the CRISPR, plasmid or BAC injections into zygotes will made in specific user background to reduce the numbers of re-crossing generations. An important role as facility leader is also the motivation of employees through it’s effective incentive plans so that the employees provide fullest co-operation.

Biography:

Mrs Holder-March, is a goal driven healthcare executive with over 31 years of leadership and training experience. She is also well known and respected in the UK and USA for her professionalism, her vast experience and portfolio of managing Corporate & Clinical Governance, Information Governance, Risk Management, Operations, System Resilience, Claims, Audit and Health and Safety in both the public and private healthcare sector. Drawing on her experience working with a wide range of companies of all sizes, from all sectors, Michaelene is an enthusiastic and inspirational coach, also a strategic advisor in the reorganising companies and advising CEOs and senior management, specialises in revitalising companies, ensuring that business objectives are achieved through having the right people in the right roles. Michaelene Gail Holder-March is a qualified teacher, nurse & midwife with registrations both in the UK & USA; she also holds a LLB and MBA in Management. She is a strong advocate of hands-on, inquiry based learning, she actively involves herself in a variety of charitable community service, mentoring /coaching others to follow her lead.

Abstract:

Technology is swiftly changing the landscape of care and delivery frameworks whereby healthcare organisations can now help patients through the utilisation  of  Internet  of  Things (IoT) technologies / systems to improve patients’ health outcomes and experiences by using rich health data and insights to enable a holistic patient diagnosis. Globally healthcare organisations are unconsciously challenged  to keep stride with patient behaviour and expectations for digitally mobile and accessible systems of care.

There are hurdles for healthcare organisations in regards to the deployment of Internet  of Things (IoT) Technologies this includes the lack of interoperability with current patient record electronic system, suppliers accountability  for failures, data  storage, consent and  data sharing, password protections and the management of the multiple connected devices from various suppliers. Other published hurdles are the tremendous quantity of  hospital  and multiple streams of patient data from various devices and readiness for the hospitals  information technology departments to manage data security, compliance with information governance, data regulations and cyber security which are to be risk managed on a daily  basis. Despite the hurdles  the benefits of fully embracing Internet  of  Things  (IoT) Technologies within healthcare is a welcome advancement in modern healthcare.

Biography:

A K Saxena, is actively involved in the domain of Medicinal Chemistry & CADD, drug discovery and development research. He has 45 years of research experience with 200 research publications, 19 reviews/articles in books and/monographs, 72 patents and has delivered >180 invited lectures, chaired >45 sessions. He is Fellow of Royal Society of Chemistry, UK, Editorial Board Member of different prominent journals like, Medicinal Chemistry Research, SAR and QSAR in Environmental Research, online International journal ARKIVOC, and Patent Evaluator: Current Drugs, UK. He is also series Editor for book series “Topics in Medicinal Chemistry” published by Springer Verlag.

Abstract:

In recent years tuberculosis (TB) chemotherapy is dependent on drugs targeting bacterial metabolism with bactericidal action having no effect on dormant or latent or metabolically inactive bacilli that target cell division. The ATP synthase is a ubiquitous enzyme in energy metabolism due to its involvement in the generation of sufficient amount of ATP and/or in generating a proton motive force (PMF) in mycobacteria during adverse conditions of low oxygen environment and nutrient deficiency. This pivotal role of ATP synthase is targeted by the diarylquinoline TMC207 that kills Mycobacterium tuberculosis. Utilizing the state-of-the-art medicinal chemistry approach the quinoline class of aryl-sulfonamides has been identified as potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors. Among a series of compounds synthesized which were effective in vitro on ATP synthase, the lead compound [N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,3-dichlo-r obenzene sulfonamide] exhibited excellent selectivity (mycobacterium ATPase IC50 = 0.51 µM, mammalian ATPase IC50 >100 µM, and selectivity >200) and is also active in the hypoxic culture of non replicating M. tuberculosis at 100 µg/mL (32-fold of its MIC) as compared to positive control isoniazid [approximately 0.2 log10 reduction in CFU at 5 lg/mL (50-fold of its MIC)]. Docking of the best compound on homology modeled ATP synthase revealed the participation of the protonated tertiary amine and hydroxyl group to interact with the carboxylate oxygen of Glu61 that is similar to TMC207. The study provides a deep understanding about the structural requirements for ATP synthase inhibitors helpful in the discovery of novel chemical entities.

Biography:

Azza Mahmoud Kamel is currently working as Emirate Professor of Clinical Pathology at National Cancer Institute, Cairo University, Egypt since 2007. Previously she worked as Professor of Clinical Pathology (1986- 2007) at National Cancer Institute, Cairo University, Egypt, Founder and Head of BMT Lab. Unit (1993- 2007) and Head of Clinical Pathology Department (2005-2007). She pursued her Medical Degree (MB, BCh), Faculty of Medicine, Cairo University (June 1968), Master Degree (MSc) in Clinical Pathology, Faculty of Medicine, Cairo University (October 1972) and Doctorate Degree (MD) in Clinical Pathology(Immunology/ Hematology), Faculty of Medicine, Cairo University (July 1976). She has 165 publications in many reputed journals. She conducted many workshops and completed many research projects. She received many awards like State Award in Medicine (1989), Medal of Excellence from the Egyptian Government (1994). She is an active member of Egyptian Society of Cancer, International Society of Hematology, European and African division (ISH), European Association of Hematology (EHA), American Association of Cancer Research (AACR), International Society of Thrombosis and Hemostasis (ISTH).

Abstract:

Cell-free indicates DNA that is found freely in the blood without a nucleus. Circulating cell-free DNA (ccf-DNAs) were first identified by Mandel and Metais in 1948 but their association with disease was not confirmed till 1977 when their increased level in the plasma/serum of cancer patients was proved. In healthy individuals, the main source of ccf-DNA is apoptotic cells which release uniform DNA fragments 185 to 200 base by a programmed enzymatic cleavage; the level is extremely variable but is usually low to negligible. Cancer cells release different and longer DNA fragments resulting from necrosis, autophagy, or mitotic catastrophe; the chance of an active release from cells was also reported and the levels are much higher than in healthy individuals. However, increased levels of ccf-DNA were observed in many diseases including leukemia, solid tumors, pulmonary embolism, myocardial infarction, tissue trauma, and chronic inflammatory diseases. This broad prevalence of diseases with potentially elevated ccf-DNA levels limits the diagnostic specificity and no cutoff value of plasma DNA concentration produced performance characteristics that would make it a good screening tool for neoplastic diseases. Thus a more refined approach was applied by calculating the ratio between cancer cell-derived ccf-DNA and normal cell-derived ccf-DNA in what is called DNA integrity index. More recently detection of tumor-specific molecular aberrations in the ccf-DNA is performed, what is called liquid biopsy. Many studies reported increased serum concentration and DNA integrity index in various solid tumors including breast, gynecological malignancy, HCC and acute myeloid leukemia. The analysis of the length of circulating DNA in plasma was reported as a sensitive marker for solid tumor detection and it was claimed to discriminate between benign and malignant lesions. The rationale of liquid biopsy is that mutations detected in ccf-DNA are highly specific of cancer and can clearly identify circulating tumor DNA (ct-DNA). Ct-DNA was explored as a prognostic or predictive marker for cancer detection; the studies suggested potential clinical applications. The analysis of ct-DNA ranges in scale from single mutations to whole-genome analyses. Liquid biopsy has many advantages compared to conventional sampling methods. The latter is subject to procedural complications, difficulty in obtaining sufficient material of adequate quality for genomic profiling and sampling biases that arise from genetic heterogeneity. A liquid biopsy is also superior to the conventional monitoring methods namely tumor markers that often lack specificity and imaging which exposes patients to ionizing radiation and has limited resolution. Promising as it is ccf-DNA and ct-DNA assays need scrupulous standardization to overlap discrepancies in sensitivities across various studies. However, sample collection is convenient, minimally invasive, and it avoids the need for tumor tissue biopsies. Analyzes of ccf- DNA and ct-DNA may have the potential to complement or replace existing cancer tissue and blood biomarkers in the future.

Biography:

Abstract:

Ultrabithorax (Ubx) is a Drosophila melanogaster transcription factor protein the the Bondos group discovered has the ability to form ordered materials in vitro. Ubx monomers are produced in E.coli and, following purification, are suspended in a buffer solution and where they do not aggregate in the volume of the solution when refrigerated. When allowed to rest at room temperature, the monomer self assembles at the air/water interface through nucleation, fibril formation and, eventually, film integration. The the self assembled film can then be pulled into a fibre with diameters in the range of 2–50 μm or lifted off as a film with microscale thickness. These materials are highly elastic and maintain physical properties through cycles of drying and re-hydrating. Novel functions can be directly incorporated into Ubx-based materials via gene fusion to produce chimeric polypeptides capable of both self-assembly and the desired chemical reactivity. Unlike most protein-based materials, the gentle conditions under which Ubx self-assembles enable incorporation of active heterologous proteins. This talk will review recent work on the continued development of this unique materials system including mechanical properties enabled by dityrosine bonding between monomers, dynamics of surface film assembly, and advances in Ubxbased materials production.

Biography:

Digdem M Siyez is a Professor in the Department of Counseling and Guidance at the Dokuz Eylul University in Turkey. She received her PhD in Counseling and Guidance at the Dokuz Eylul University. Her current research interests include Sexual Health, Gender, Adolescence Development and Prevention.

Abstract:

Statement of the Problem: Infertility is a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Infertility is more pervasive in developing countries than developed countries. It is observed that studies on the level of knowledge about infertility in Turkey are very limited and these studies were carried out in small samples. The aim of this research was to examine the knowledge levels of university students on infertility.

Methodology & Theoretical Orientation: Participants were 9693 Bachelor’s students (51.6% female, 48.4% male) from 21 universities in Turkey. The data was collected via Infertility Knowledge Test which is developed by the researchers. The responses to the Infertility Knowledge Test, which consists of 33 items, are marked as "true", "false" and "do not know".

Findings: An important finding obtained from this study was 68.4% of the respondents knew that women’s fertility potential decreased after age 40 compared to 20 years old, while 10% of the participants knew that sperm quality in men deteriorated with age and 23.6% of the participants knew that age was a determining factor in male infertility. The majority of participants knew that smoking, drugs and exposure to heavy chemicals could cause infertility. More than half of the participants didn’t know that timing of sexual intercourse and being extremely weak could cause infertility.

Conclusion & Significance: It can be said that the participants' knowledge level about infertility was low and participants were not aware of some of the preventable risk factors related to infertility. For this reason, it is recommended that awareness raising activities should be undertaken.

Biography:

Abstract:

Biography:

Petra Perner is the director of the Institute of Computer Vision and Applied Computer Sciences IBaI. She received her Diploma degree in electrical engineering and her PhD degree in computer science for the work on “Data Reduction Methods for Industrial Robots with Direct Teach-in-Programing”. Her habilitation thesis was about “A Methodology for the Development of Knowledge-Based Image-Interpretation Systems". She has been the principal investigator of various national and international research projects. Her research interest is image/signal analysis and interpretation, machine learning, data mining, big data, machine learning, image mining and case-based reasoning.

Abstract:

The aim of our research was to develop a method that allows us automatically to discover the decision rules for diagnosing images in normal and abnormal images. We used a dataset of images that came from an endoscopic video system used for colon examination.  The data set contains 283 normal tissue images and 61 polyp images. One must decide if the image shows a polyp or not.  This is a two class problem. The unequal number of the data in the two classes makes our problem to an unbalanced data set problem.  The polyps in the images were identified and selected by a “well-trained” medical expert. The 283 normal images consist of dark regions and reflection. We describe the images by our novel random set texture descriptor. The resulting data set was used to train a decision tree with our tool “Decision Master”. For the full unequally distributed data set we achieved an error rate of 9.88% based on cross-validation.  We achieved an error rate of 1.67% when we created a data set with equally distributed data in each class.  The results show that decision tree induction based on “Decision Master” and image analysis based on our novel texture descriptor is an excellent method to mine images for the decision rules even when the data set is unbalanced.  Our texture descriptor gives a flexible way to describe the appearance of the medical objects. The accuracy of the derived rules can be improved when the data set is made equally distributed.

Biography:

Ankita Tuknayat is pursuing her post-graduate residency in Dermatology in Government Medical College and Hospital, Chandigarh, India. She has 2 international publications namely Cyclophosphamide Induced Hearing loss – Reversibility and Preventive strategies in  American Journal of Therapeutics and Extensive Donor Site Keloids in Follicular Unit Extraction Hair Transplantation in International Journal of Trichology. She has presented various papers as Speaker and multiple posters in various dermatology conferences across India. She has also won a second award in a poster presentation in a national conference on Dermatophytosis conducted in Post Graduate Institute of Medical Education and Research in 2017. She is an avid participant in various activities of Chandigarh Dermatology Society.

Abstract:

Introduction

Terra firma forme dermatosis (TFFD) is an acquired, benign disorder of keratinization characterized by retention hyperkeratosis presenting as dirt like plaques which are resistant to washing but can be removed with forceful swabbing with alcohol pad. The exact etiopathogenesis of the disease is unknown but is thought to be due to delay in the maturation of keratinocytes, with melanin retention and accumulation of sebum &amp; corneocytes .

Case report

A 29 years old female presented with complaints of persistent brownish-grey dirt-like skin lesions over her face and neck along with matting of hairs from last 5 years for which she had taken multiple consultations but with no relief.Histopathology was consistent with TFFD. The lesions were wiped off with isopropyl alcohol, confirming the diagnosis. On enquiring she had some psychiatric issues for which she was evaluated.

Discussion

Dermatitis neglecta/passivata involves self neglect due to underlying psychological morbidity. This has not been described in the recently described TFFD . But in our patient a psychiatric component was elicited and histopathology was consistent with TFFD. This propels us to think that dermatitis neglecta and TFFD which is a new entity may be a continuum of the same spectrum.

Biography:

Marc Delcommenne is currently an Director of Research and Development at MBL International / MBL Bion. He is also an professor works in Rush University Medical Center, Chicago. He has published many articles in reputed journals. His research interest includes Biology, Immunology & microbiology.

Abstract:

Rapid discovery and identification of many new and novel tumor associated epitopes and neoantigens can potentially result in potent cancer vaccines. However, no verdict of immunogenicity may be made without a rapid method to measure the binding of these peptides to MHC of the hosts.   While existing methodologies rely on UV cleavage of exiting peptide on monomeric MHC complexes and a subsequent lengthy tetramerization procedure, the platform presented here produces tetramers ready for cell staining to detect antigen-specific T cells in just four hours.  We have devised a fast and user-friendly peptide exchange tetramer platform (also referred as QuickSwitch™ Quant) that can both help determine binding of novel peptides, including neoantigens, to MHC class I molecules and generate new specificity MHC class I tetramers for peptide specific T cell detection.  We have developed a platform / kit for the generation of new specificity MHC tetramers, whereby a peptide of interest and a peptide exchange factor is incubated with a fluorescently labeled tetramer containing a special exiting peptide.  This study aimed to determine whether the peptide exchange HLA-A*02:01 tetramer platform can be used for evaluating the biological activity of a vaccine.  The tested vaccine was DPX-Survivac, an ovarian cancer vaccine candidate which consists of several survivin peptide antigens that are each restricted to a different human class I allele. We evaluated the specificity and sensitivity of the platform for assessing the biological activity of SurA2.M, an HLA-A2-restricted peptide, in DPX-Survivac.  We tested the detection of the peptide prepared individually in a buffered solution or in the DPX-Survivac vaccine prepared in an aqueous formulation.  Results indicate that peptide exchange rate of SurA2.M is similar whether it is dissolved individually in a buffered solution or in a matrix of the vaccine.  Thus, by optimizing a concentration curve using individual peptides, the peptide exchange tetramer platform can be used to examine the binding of peptide vaccines in a mixture and to quantify the concentration of HLA-A2 restricted peptides in simple solutions or more complex formulations. 

Biography:

Aram Cargill is the director of The Adaption Apex Lab and Change Challenge working alongside Dr Kaalii Cargill who completed her PhD in psychology and Melbourne University Australia. She has been the past President of SCAPE (Society of Counselling and Psychotherapy Educators) and ISOCSS (International Society of Clinical and Counselling Supervisors), and past Vice-President of PACFA (Psychotherapy and Counselling Federation of Australia). As well as working in private practice (Kairos Centre ) for 40 years. Aram Cargill is also on the board of directs for Ledsen and an executive director a Kanga innovation. Working together the two have adapted DARE ( Deception Analysis Reasoning Engine ) for advanced lexical psychometric testing through mobile phone technology     

Abstract:

The digital age has made deception manipulative profiles far more attractive and simpler, not only for predatory behaviour but also in terms of the developing personality.

As the information age develops into the age of augmentation (Harris 2016 ), our understanding of ourselves becomes ever more relevant  as our digital identities grow in importance and stature.  

In the light of this, understanding what has been referred to as “the dark triad”  (Paulhus & Williams, 2002 ) or negative personality traits on a day to day, pedestrian level becomes ever more important. The very fact that our digital identities express not only our conscious choices but also our subconscious wants and desires and unconscious needs, it is important that our profile of the dark triad becomes more refined. If left in the “dark”, these traits may become evident in some type of externalised event. Narcissism, machiavellianism, and psychopathy are encouraged and exacerbated by technology (Twenge & Foster, 2010). These personality traits have become ever more alluring and seductive because of ability to construct digital identities that may take precedence over authentic identities.

We have steered away from general profiling and testing of these traits because of the criticisms of verbal descriptors of individual differences (lexical hypothesis) especially in in terms of the dark triad because of negative language and its impact on self-description.

The developments in artificial intelligence identify attitudes, emotions, and moods during lexical hypothesis testing, and give the framework greater extension and accuracy in trait profiling of individuals. This in turn gives more proficiency to language-based profiling of the dark triad. Developments in the cost-effectiveness of big data support this. 

Our society now requires greater base line awareness, observation, monitoring and management long before the deception manipulative profiles of the digital age hit the radar in negative consequences or predatory behaviour.